morphine and angiogenesis in hypertensive animals

Morphine and Angiogenesis in Hypertensive Animals

Morphine and Angiogenesis in Hypertensive Animals

In a recent published paper, Pourshanazari et al found that morphine enhanced angiogenesis in murine matrigel method in sham and two-kidney one-clip (2K-1C) hypertensive animals and they concluded that this effect is via NO pathway (1). Morphine acts both directly and indirectly on angiogenesis, however, the results are contradictory. It seems that the different effect of morphine on angiogenes...

Effects of Low-dose Morphine on Nitric Oxide Concentration and Angiogenesis in Two-kidney One Clip Hypertensive Rats

Objective(s) We investigated the effects of low-dose morphine on nitric oxide (NO) and angiogenesis in two-kidney one clip hypertensive (2K1C) rats. Materials and Methods Male rats were divided into two groups: sham-clip operated and 2K1C. Each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. Blood pressure, heart rate, plasma renin activity (PRA), NO concentration an...

effects of low-dose morphine on nitric oxide concentration and angiogenesis in two-kidney one clip hypertensive rats

objective(s) we investigated the effects of low-dose morphine on nitric oxide (no) and angiogenesis in two-kidney one clip hypertensive (2k1c) rats. materials and methods male rats were divided into two groups: sham-clip operated and 2k1c. each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. blood pressure, heart rate, plasma renin activity (pra), no concentration and m...

Low Dose Morphine Enhances Morphine Antinociception Effects in the Animals Pretreated with Selective and Non-Selective Phosphodiestrase Inhibitors

       In this study, we investigated the interactive effects of intraperitoneal (i.p.) injections of three different phosphodiesterase inhibitors (PDEIs) on morphine-induced analgesia in mice using tail-flick method. Subcutaneous administration of morphine (1, 3 and 6 mg/kg) caused significant antinociceptive effects in a dose dependent manner. Administration of pentoxifylline (12.5, 25, 50 an...

Effects of Low-dose Morphine on Nitric Oxide Concentration and Angiogenesis in Two-kidney One Clip Hypertensive Rats

OBJECTIVES We investigated the effects of low-dose morphine on nitric oxide (NO) and angiogenesis in two-kidney one clip hypertensive (2K1C) rats. MATERIALS AND METHODS MALE RATS WERE DIVIDED INTO TWO GROUPS: sham-clip operated and 2K1C. Each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. Blood pressure, heart rate, plasma renin activity (PRA), NO concentration and m...